KPV is one of the smallest peptides in clinical conversation, just three amino acids, and that simplicity is central to its appeal. It is the active anti-inflammatory tail of a larger hormone, isolated so that the anti-inflammatory signal can be used without the pigmentation effects of the parent molecule. At Body Works it is compounded and used under provider supervision.
KPV is a tripeptide made of lysine, proline, and valine, corresponding to the final three amino acids of alpha-melanocyte stimulating hormone. Researchers identified this fragment as carrying much of the parent hormone’s anti-inflammatory activity.
Isolating it separates the anti-inflammatory effect from the pigmentation activity, which is the mechanistic reason KPV is discussed as a distinct therapy rather than as a melanocortin compound.
Research has focused on KPV in inflammatory conditions of the gut and skin. Preclinical models of colitis have been a particular focus, examining whether KPV can reduce inflammatory signaling in the intestinal lining.
Topical and oral applications have both been studied. As with most peptides in this category, the evidence is largely preclinical, and human clinical trial data is limited. Patients typically raise KPV in the context of inflammatory gut symptoms or inflammatory skin conditions.
KPV is not FDA-approved. It is prepared by compounding pharmacies and used under provider supervision at Body Works.
Inflammatory bowel conditions and persistent inflammatory skin conditions are genuine medical diagnoses that warrant proper evaluation. KPV is not a substitute for that workup, and your provider will say so directly if your symptoms point toward a condition requiring formal diagnosis and management.
Body Works Franklin
1113 Murfreesboro Rd Suite 307
Franklin, TN 37064
(615) 790-2548
By appointment Monday through Friday
Body Works Nolensville
210 Burkitt Commons Ave
Nolensville, TN 37135
(615) 941-1000
By appointment Monday through Friday
KPV is a tripeptide made of lysine, proline, and valine, corresponding to the final three amino acids of alpha-melanocyte stimulating hormone. That fragment carries much of the parent hormone’s anti-inflammatory activity without its pigmentation effects.
No. KPV is not FDA-approved. It is prepared by compounding pharmacies and used under provider supervision at Body Works, with candidacy assessed individually.
Research has focused on inflammatory conditions of the gut and skin, with preclinical models of colitis a particular focus. Both topical and oral applications have been studied. The evidence is largely preclinical and human trial data is limited.
KPV is not a treatment for diagnosed inflammatory bowel disease and is not a substitute for proper evaluation. Inflammatory bowel conditions are genuine medical diagnoses requiring formal workup and management. Your provider will say so directly if your symptoms point that direction.
KPV is used in several formats including oral and topical preparations, depending on whether the target is gut or skin. Your provider will match the format to your goal at your consultation.
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